7NE6

Human TET2 in complex with unfavourable DNA substrate.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006211	biological_process	5-methylcytosine catabolic process
A	0070579	molecular_function	5-methylcytosine dioxygenase activity
A	0080111	biological_process	DNA demethylation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	BINDING: BINDING => ECO:0000269|PubMed:24315485

Chain	Residue	Details
A	CYS1133
A	CYS1135
A	CYS1193
A	HIS1219
A	CYS1221
A	ARG1261
A	CYS1271
A	CYS1273
A	CYS1289
A	CYS1298
A	CYS1358
A	CYS1374
A	HIS1380
A	HIS1382
A	ASP1384
A	ASN1387
A	HIS1416
A	HIS1881
A	ARG1896
A	TYR1902
A	HIS1912

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25557551

Chain	Residue	Details
A	LYS1299

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