7N8S

LINE-1 endonuclease domain complex with DNA

Summary for 7N8S

• Entry DOI: 10.2210/pdb7n8s/pdb
• Descriptor: LINE-1 retrotransposable element ORF2 protein, DNA (5'-D(*CP*CP*TP*TP*AP*AP*AP*AP*AP*GP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*GP*CP*TP*CP*CP*TP*TP*TP*TP*TP*AP*AP*GP*GP*A)-3') (3 entities in total)
• Functional Keywords: endonuclease, non-ltr retrotransposon, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 36250.25

Authors

Korolev, S.,Miller, I. (deposition date: 2021-06-15, release date: 2021-10-13, Last modification date: 2023-10-18)

• Primary citation: Miller, I.,Totrov, M.,Korotchkina, L.,Kazyulkin, D.N.,Gudkov, A.V.,Korolev, S.; Structural dissection of sequence recognition and catalytic mechanism of human LINE-1 endonuclease.; Nucleic Acids Res., 49:11350-11366, 2021; PubMed: 34554261; DOI: 10.1093/nar/gkab826

Experimental method

X-RAY DIFFRACTION (2.79 Å)