7N8S
LINE-1 endonuclease domain complex with DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | LINE-1 retrotransposable element ORF2 protein | polymer | 238 | 27073.2 | 1 | UniProt (O00370) Pfam (PF03372) | Homo sapiens (Human) | ORF2p |
| 2 | B (D) | DNA (5'-D(*CP*CP*TP*TP*AP*AP*AP*AP*AP*GP*GP*AP*GP*CP*T)-3') | polymer | 15 | 4602.0 | 1 | Homo sapiens | ||
| 3 | C (C) | DNA (5'-D(*GP*CP*TP*CP*CP*TP*TP*TP*TP*TP*AP*AP*GP*GP*A)-3') | polymer | 15 | 4575.0 | 1 | Homo sapiens |
Sequence modifications
A: 1 - 238 (UniProt: O00370)
| PDB | External Database | Details |
|---|---|---|
| Ile 15 | Val 15 | conflict |
| Ala 21 | Pro 21 | conflict |
| Ala 145 | Asp 145 | engineered mutation |
| Thr 152 | Ile 152 | conflict |
| Ala 175 | Thr 175 | conflict |
| Lys 226 | Tyr 226 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 36250.2 | |
| All* | Total formula weight | 36250.2 |
