7MYM
Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH
Summary for 7MYM
Entry DOI | 10.2210/pdb7mym/pdb |
Descriptor | Dihydrofolate reductase, ARGININE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
Functional Keywords | dihydrofolate reductase, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 3 |
Total formula weight | 57893.86 |
Authors | Erlandsen, H.,Wright, D.,Krucinska, J. (deposition date: 2021-05-21, release date: 2022-06-01, Last modification date: 2023-10-18) |
Primary citation | Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5:459-459, 2022 Cited by PubMed: 35562546DOI: 10.1038/s42003-022-03384-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.04 Å) |
Structure validation
Download full validation report