7MYM

Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH

Summary for 7MYM

Entry DOI	10.2210/pdb7mym/pdb
Descriptor	Dihydrofolate reductase, ARGININE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywords	dihydrofolate reductase, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	3
Total formula weight	57893.86
Authors	Erlandsen, H.,Wright, D.,Krucinska, J. (deposition date: 2021-05-21, release date: 2022-06-01, Last modification date: 2023-10-18)
Primary citation	Krucinska, J.,Lombardo, M.N.,Erlandsen, H.,Estrada, A.,Si, D.,Viswanathan, K.,Wright, D.L. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens. Commun Biol, 5:459-459, 2022 Cited by PubMed: 35562546 DOI: 10.1038/s42003-022-03384-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.04 Å)

Structure validation