7MYM
Crystal structure of Escherichia coli dihydrofolate reductase in complex with TRIMETHOPRIM and NADPH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, C, B) | Dihydrofolate reductase | polymer | 159 | 18019.3 | 3 | UniProt (P0ABQ5) Pfam (PF00186) UniProt (by SIFTS) (P0ABQ4) | Escherichia coli | |
| 2 | D, I (A, C) | ARGININE | non-polymer | 175.2 | 2 | Chemie (ARG) | |||
| 3 | E, J, M (A, C, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 3 | Chemie (NAP) PubChem (4412) PubChem (46936685) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (5885) PubChem (165382010) | |||
| 4 | F, K, N (A, C, B) | TRIMETHOPRIM | non-polymer | 290.3 | 3 | Chemie (TOP) PubChem (5578) | |||
| 5 | G, H, L, O (A, C, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | P, Q, R (A, C, B) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 54058.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3835.8 | |
| All* | Total formula weight | 57893.9 |
