7MS5
Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 4-(4-(4-(3,4-difluoro-phenyl)-piperidin-1-ylsulfonyl)-phenyl)-4-oxo-butanoic acid
Summary for 7MS5
Entry DOI | 10.2210/pdb7ms5/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 5, ZINC ION, 4-{4-[4-(3,4-difluorophenyl)piperidine-1-sulfonyl]phenyl}-4-oxobutanoic acid, ... (6 entities in total) |
Functional Keywords | usp5, ubiquitin, usp, ubiquitin specific protease, structural genomics, structural genomics consortium, sgc, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 28178.28 |
Authors | Mann, M.K.,Zepeda-Velazquez, C.A.,Alvarez, H.G.,Dong, A.,Kiyota, T.,Aman, A.,Arrowsmith, C.H.,Al-Awar, R.,Harding, R.J.,Schapira, M.,Structural Genomics Consortium (SGC) (deposition date: 2021-05-10, release date: 2021-06-09, Last modification date: 2023-10-18) |
Primary citation | Mann, M.K.,Zepeda-Velazquez, C.A.,Gonzalez-Alvarez, H.,Dong, A.,Kiyota, T.,Aman, A.M.,Loppnau, P.,Li, Y.,Wilson, B.,Arrowsmith, C.H.,Al-Awar, R.,Harding, R.J.,Schapira, M. Structure-Activity Relationship of USP5 Inhibitors. J.Med.Chem., 64:15017-15036, 2021 Cited by PubMed: 34648286DOI: 10.1021/acs.jmedchem.1c00889 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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