7M8V
Human CYP11B2 in complex with LCI699
Summary for 7M8V
Entry DOI | 10.2210/pdb7m8v/pdb |
Descriptor | Cytochrome P450 11B2, mitochondrial, 4-[(4R,5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total) |
Functional Keywords | aldosterone synthase, cyp11b2, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 12 |
Total formula weight | 678507.86 |
Authors | Scott, E.E.,Brixius-Anderko, S. (deposition date: 2021-03-30, release date: 2021-06-16, Last modification date: 2023-10-18) |
Primary citation | Brixius-Anderko, S.,Scott, E.E. Aldosterone Synthase Structure With Cushing Disease Drug LCI699 Highlights Avenues for Selective CYP11B Drug Design. Hypertension, 78:751-759, 2021 Cited by PubMed: 34247511DOI: 10.1161/HYPERTENSIONAHA.121.17615 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.08 Å) |
Structure validation
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