7M8V

Human CYP11B2 in complex with LCI699

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002017	biological_process	regulation of blood volume by renal aldosterone
A	0003091	biological_process	renal water homeostasis
A	0004497	molecular_function	monooxygenase activity
A	0004507	molecular_function	steroid 11-beta-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006066	biological_process	alcohol metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006700	biological_process	C21-steroid hormone biosynthetic process
A	0006704	biological_process	glucocorticoid biosynthetic process
A	0006705	biological_process	mineralocorticoid biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016125	biological_process	sterol metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0032342	biological_process	aldosterone biosynthetic process
A	0032870	biological_process	cellular response to hormone stimulus
A	0034650	biological_process	cortisol metabolic process
A	0034651	biological_process	cortisol biosynthetic process
A	0035865	biological_process	cellular response to potassium ion
A	0046872	molecular_function	metal ion binding
A	0047783	molecular_function	corticosterone 18-monooxygenase activity
A	0055075	biological_process	potassium ion homeostasis
A	0055078	biological_process	sodium ion homeostasis
A	0071375	biological_process	cellular response to peptide hormone stimulus
B	0002017	biological_process	regulation of blood volume by renal aldosterone
B	0003091	biological_process	renal water homeostasis
B	0004497	molecular_function	monooxygenase activity
B	0004507	molecular_function	steroid 11-beta-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006066	biological_process	alcohol metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0006700	biological_process	C21-steroid hormone biosynthetic process
B	0006704	biological_process	glucocorticoid biosynthetic process
B	0006705	biological_process	mineralocorticoid biosynthetic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008395	molecular_function	steroid hydroxylase activity
B	0016125	biological_process	sterol metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0032342	biological_process	aldosterone biosynthetic process
B	0032870	biological_process	cellular response to hormone stimulus
B	0034650	biological_process	cortisol metabolic process
B	0034651	biological_process	cortisol biosynthetic process
B	0035865	biological_process	cellular response to potassium ion
B	0046872	molecular_function	metal ion binding
B	0047783	molecular_function	corticosterone 18-monooxygenase activity
B	0055075	biological_process	potassium ion homeostasis
B	0055078	biological_process	sodium ion homeostasis
B	0071375	biological_process	cellular response to peptide hormone stimulus
C	0002017	biological_process	regulation of blood volume by renal aldosterone
C	0003091	biological_process	renal water homeostasis
C	0004497	molecular_function	monooxygenase activity
C	0004507	molecular_function	steroid 11-beta-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006066	biological_process	alcohol metabolic process
C	0006629	biological_process	lipid metabolic process
C	0006694	biological_process	steroid biosynthetic process
C	0006700	biological_process	C21-steroid hormone biosynthetic process
C	0006704	biological_process	glucocorticoid biosynthetic process
C	0006705	biological_process	mineralocorticoid biosynthetic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008395	molecular_function	steroid hydroxylase activity
C	0016125	biological_process	sterol metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0020037	molecular_function	heme binding
C	0032342	biological_process	aldosterone biosynthetic process
C	0032870	biological_process	cellular response to hormone stimulus
C	0034650	biological_process	cortisol metabolic process
C	0034651	biological_process	cortisol biosynthetic process
C	0035865	biological_process	cellular response to potassium ion
C	0046872	molecular_function	metal ion binding
C	0047783	molecular_function	corticosterone 18-monooxygenase activity
C	0055075	biological_process	potassium ion homeostasis
C	0055078	biological_process	sodium ion homeostasis
C	0071375	biological_process	cellular response to peptide hormone stimulus
D	0002017	biological_process	regulation of blood volume by renal aldosterone
D	0003091	biological_process	renal water homeostasis
D	0004497	molecular_function	monooxygenase activity
D	0004507	molecular_function	steroid 11-beta-monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006066	biological_process	alcohol metabolic process
D	0006629	biological_process	lipid metabolic process
D	0006694	biological_process	steroid biosynthetic process
D	0006700	biological_process	C21-steroid hormone biosynthetic process
D	0006704	biological_process	glucocorticoid biosynthetic process
D	0006705	biological_process	mineralocorticoid biosynthetic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008395	molecular_function	steroid hydroxylase activity
D	0016125	biological_process	sterol metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0020037	molecular_function	heme binding
D	0032342	biological_process	aldosterone biosynthetic process
D	0032870	biological_process	cellular response to hormone stimulus
D	0034650	biological_process	cortisol metabolic process
D	0034651	biological_process	cortisol biosynthetic process
D	0035865	biological_process	cellular response to potassium ion
D	0046872	molecular_function	metal ion binding
D	0047783	molecular_function	corticosterone 18-monooxygenase activity
D	0055075	biological_process	potassium ion homeostasis
D	0055078	biological_process	sodium ion homeostasis
D	0071375	biological_process	cellular response to peptide hormone stimulus
E	0002017	biological_process	regulation of blood volume by renal aldosterone
E	0003091	biological_process	renal water homeostasis
E	0004497	molecular_function	monooxygenase activity
E	0004507	molecular_function	steroid 11-beta-monooxygenase activity
E	0005506	molecular_function	iron ion binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006066	biological_process	alcohol metabolic process
E	0006629	biological_process	lipid metabolic process
E	0006694	biological_process	steroid biosynthetic process
E	0006700	biological_process	C21-steroid hormone biosynthetic process
E	0006704	biological_process	glucocorticoid biosynthetic process
E	0006705	biological_process	mineralocorticoid biosynthetic process
E	0008202	biological_process	steroid metabolic process
E	0008203	biological_process	cholesterol metabolic process
E	0008395	molecular_function	steroid hydroxylase activity
E	0016125	biological_process	sterol metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
E	0020037	molecular_function	heme binding
E	0032342	biological_process	aldosterone biosynthetic process
E	0032870	biological_process	cellular response to hormone stimulus
E	0034650	biological_process	cortisol metabolic process
E	0034651	biological_process	cortisol biosynthetic process
E	0035865	biological_process	cellular response to potassium ion
E	0046872	molecular_function	metal ion binding
E	0047783	molecular_function	corticosterone 18-monooxygenase activity
E	0055075	biological_process	potassium ion homeostasis
E	0055078	biological_process	sodium ion homeostasis
E	0071375	biological_process	cellular response to peptide hormone stimulus
F	0002017	biological_process	regulation of blood volume by renal aldosterone
F	0003091	biological_process	renal water homeostasis
F	0004497	molecular_function	monooxygenase activity
F	0004507	molecular_function	steroid 11-beta-monooxygenase activity
F	0005506	molecular_function	iron ion binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006066	biological_process	alcohol metabolic process
F	0006629	biological_process	lipid metabolic process
F	0006694	biological_process	steroid biosynthetic process
F	0006700	biological_process	C21-steroid hormone biosynthetic process
F	0006704	biological_process	glucocorticoid biosynthetic process
F	0006705	biological_process	mineralocorticoid biosynthetic process
F	0008202	biological_process	steroid metabolic process
F	0008203	biological_process	cholesterol metabolic process
F	0008395	molecular_function	steroid hydroxylase activity
F	0016125	biological_process	sterol metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
F	0020037	molecular_function	heme binding
F	0032342	biological_process	aldosterone biosynthetic process
F	0032870	biological_process	cellular response to hormone stimulus
F	0034650	biological_process	cortisol metabolic process
F	0034651	biological_process	cortisol biosynthetic process
F	0035865	biological_process	cellular response to potassium ion
F	0046872	molecular_function	metal ion binding
F	0047783	molecular_function	corticosterone 18-monooxygenase activity
F	0055075	biological_process	potassium ion homeostasis
F	0055078	biological_process	sodium ion homeostasis
F	0071375	biological_process	cellular response to peptide hormone stimulus
G	0002017	biological_process	regulation of blood volume by renal aldosterone
G	0003091	biological_process	renal water homeostasis
G	0004497	molecular_function	monooxygenase activity
G	0004507	molecular_function	steroid 11-beta-monooxygenase activity
G	0005506	molecular_function	iron ion binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006066	biological_process	alcohol metabolic process
G	0006629	biological_process	lipid metabolic process
G	0006694	biological_process	steroid biosynthetic process
G	0006700	biological_process	C21-steroid hormone biosynthetic process
G	0006704	biological_process	glucocorticoid biosynthetic process
G	0006705	biological_process	mineralocorticoid biosynthetic process
G	0008202	biological_process	steroid metabolic process
G	0008203	biological_process	cholesterol metabolic process
G	0008395	molecular_function	steroid hydroxylase activity
G	0016125	biological_process	sterol metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
G	0020037	molecular_function	heme binding
G	0032342	biological_process	aldosterone biosynthetic process
G	0032870	biological_process	cellular response to hormone stimulus
G	0034650	biological_process	cortisol metabolic process
G	0034651	biological_process	cortisol biosynthetic process
G	0035865	biological_process	cellular response to potassium ion
G	0046872	molecular_function	metal ion binding
G	0047783	molecular_function	corticosterone 18-monooxygenase activity
G	0055075	biological_process	potassium ion homeostasis
G	0055078	biological_process	sodium ion homeostasis
G	0071375	biological_process	cellular response to peptide hormone stimulus
H	0002017	biological_process	regulation of blood volume by renal aldosterone
H	0003091	biological_process	renal water homeostasis
H	0004497	molecular_function	monooxygenase activity
H	0004507	molecular_function	steroid 11-beta-monooxygenase activity
H	0005506	molecular_function	iron ion binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006066	biological_process	alcohol metabolic process
H	0006629	biological_process	lipid metabolic process
H	0006694	biological_process	steroid biosynthetic process
H	0006700	biological_process	C21-steroid hormone biosynthetic process
H	0006704	biological_process	glucocorticoid biosynthetic process
H	0006705	biological_process	mineralocorticoid biosynthetic process
H	0008202	biological_process	steroid metabolic process
H	0008203	biological_process	cholesterol metabolic process
H	0008395	molecular_function	steroid hydroxylase activity
H	0016125	biological_process	sterol metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
H	0020037	molecular_function	heme binding
H	0032342	biological_process	aldosterone biosynthetic process
H	0032870	biological_process	cellular response to hormone stimulus
H	0034650	biological_process	cortisol metabolic process
H	0034651	biological_process	cortisol biosynthetic process
H	0035865	biological_process	cellular response to potassium ion
H	0046872	molecular_function	metal ion binding
H	0047783	molecular_function	corticosterone 18-monooxygenase activity
H	0055075	biological_process	potassium ion homeostasis
H	0055078	biological_process	sodium ion homeostasis
H	0071375	biological_process	cellular response to peptide hormone stimulus
I	0002017	biological_process	regulation of blood volume by renal aldosterone
I	0003091	biological_process	renal water homeostasis
I	0004497	molecular_function	monooxygenase activity
I	0004507	molecular_function	steroid 11-beta-monooxygenase activity
I	0005506	molecular_function	iron ion binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006066	biological_process	alcohol metabolic process
I	0006629	biological_process	lipid metabolic process
I	0006694	biological_process	steroid biosynthetic process
I	0006700	biological_process	C21-steroid hormone biosynthetic process
I	0006704	biological_process	glucocorticoid biosynthetic process
I	0006705	biological_process	mineralocorticoid biosynthetic process
I	0008202	biological_process	steroid metabolic process
I	0008203	biological_process	cholesterol metabolic process
I	0008395	molecular_function	steroid hydroxylase activity
I	0016125	biological_process	sterol metabolic process
I	0016491	molecular_function	oxidoreductase activity
I	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
I	0020037	molecular_function	heme binding
I	0032342	biological_process	aldosterone biosynthetic process
I	0032870	biological_process	cellular response to hormone stimulus
I	0034650	biological_process	cortisol metabolic process
I	0034651	biological_process	cortisol biosynthetic process
I	0035865	biological_process	cellular response to potassium ion
I	0046872	molecular_function	metal ion binding
I	0047783	molecular_function	corticosterone 18-monooxygenase activity
I	0055075	biological_process	potassium ion homeostasis
I	0055078	biological_process	sodium ion homeostasis
I	0071375	biological_process	cellular response to peptide hormone stimulus
J	0002017	biological_process	regulation of blood volume by renal aldosterone
J	0003091	biological_process	renal water homeostasis
J	0004497	molecular_function	monooxygenase activity
J	0004507	molecular_function	steroid 11-beta-monooxygenase activity
J	0005506	molecular_function	iron ion binding
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006066	biological_process	alcohol metabolic process
J	0006629	biological_process	lipid metabolic process
J	0006694	biological_process	steroid biosynthetic process
J	0006700	biological_process	C21-steroid hormone biosynthetic process
J	0006704	biological_process	glucocorticoid biosynthetic process
J	0006705	biological_process	mineralocorticoid biosynthetic process
J	0008202	biological_process	steroid metabolic process
J	0008203	biological_process	cholesterol metabolic process
J	0008395	molecular_function	steroid hydroxylase activity
J	0016125	biological_process	sterol metabolic process
J	0016491	molecular_function	oxidoreductase activity
J	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
J	0020037	molecular_function	heme binding
J	0032342	biological_process	aldosterone biosynthetic process
J	0032870	biological_process	cellular response to hormone stimulus
J	0034650	biological_process	cortisol metabolic process
J	0034651	biological_process	cortisol biosynthetic process
J	0035865	biological_process	cellular response to potassium ion
J	0046872	molecular_function	metal ion binding
J	0047783	molecular_function	corticosterone 18-monooxygenase activity
J	0055075	biological_process	potassium ion homeostasis
J	0055078	biological_process	sodium ion homeostasis
J	0071375	biological_process	cellular response to peptide hormone stimulus
K	0002017	biological_process	regulation of blood volume by renal aldosterone
K	0003091	biological_process	renal water homeostasis
K	0004497	molecular_function	monooxygenase activity
K	0004507	molecular_function	steroid 11-beta-monooxygenase activity
K	0005506	molecular_function	iron ion binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006066	biological_process	alcohol metabolic process
K	0006629	biological_process	lipid metabolic process
K	0006694	biological_process	steroid biosynthetic process
K	0006700	biological_process	C21-steroid hormone biosynthetic process
K	0006704	biological_process	glucocorticoid biosynthetic process
K	0006705	biological_process	mineralocorticoid biosynthetic process
K	0008202	biological_process	steroid metabolic process
K	0008203	biological_process	cholesterol metabolic process
K	0008395	molecular_function	steroid hydroxylase activity
K	0016125	biological_process	sterol metabolic process
K	0016491	molecular_function	oxidoreductase activity
K	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
K	0020037	molecular_function	heme binding
K	0032342	biological_process	aldosterone biosynthetic process
K	0032870	biological_process	cellular response to hormone stimulus
K	0034650	biological_process	cortisol metabolic process
K	0034651	biological_process	cortisol biosynthetic process
K	0035865	biological_process	cellular response to potassium ion
K	0046872	molecular_function	metal ion binding
K	0047783	molecular_function	corticosterone 18-monooxygenase activity
K	0055075	biological_process	potassium ion homeostasis
K	0055078	biological_process	sodium ion homeostasis
K	0071375	biological_process	cellular response to peptide hormone stimulus
L	0002017	biological_process	regulation of blood volume by renal aldosterone
L	0003091	biological_process	renal water homeostasis
L	0004497	molecular_function	monooxygenase activity
L	0004507	molecular_function	steroid 11-beta-monooxygenase activity
L	0005506	molecular_function	iron ion binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006066	biological_process	alcohol metabolic process
L	0006629	biological_process	lipid metabolic process
L	0006694	biological_process	steroid biosynthetic process
L	0006700	biological_process	C21-steroid hormone biosynthetic process
L	0006704	biological_process	glucocorticoid biosynthetic process
L	0006705	biological_process	mineralocorticoid biosynthetic process
L	0008202	biological_process	steroid metabolic process
L	0008203	biological_process	cholesterol metabolic process
L	0008395	molecular_function	steroid hydroxylase activity
L	0016125	biological_process	sterol metabolic process
L	0016491	molecular_function	oxidoreductase activity
L	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
L	0020037	molecular_function	heme binding
L	0032342	biological_process	aldosterone biosynthetic process
L	0032870	biological_process	cellular response to hormone stimulus
L	0034650	biological_process	cortisol metabolic process
L	0034651	biological_process	cortisol biosynthetic process
L	0035865	biological_process	cellular response to potassium ion
L	0046872	molecular_function	metal ion binding
L	0047783	molecular_function	corticosterone 18-monooxygenase activity
L	0055075	biological_process	potassium ion homeostasis
L	0055078	biological_process	sodium ion homeostasis
L	0071375	biological_process	cellular response to peptide hormone stimulus

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGMRQCLG

Chain	Residue	Details
A	PHE443-GLY452

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23322723","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DVQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"23322723","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FDH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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