7M8V

Human CYP11B2 in complex with LCI699

Summary for 7M8V

Entry DOI	10.2210/pdb7m8v/pdb
Descriptor	Cytochrome P450 11B2, mitochondrial, 4-[(4R,5R)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl]-3-fluorobenzonitrile, PROTOPORPHYRIN IX CONTAINING FE, ... (4 entities in total)
Functional Keywords	aldosterone synthase, cyp11b2, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	12
Total formula weight	678507.86
Authors	Scott, E.E.,Brixius-Anderko, S. (deposition date: 2021-03-30, release date: 2021-06-16, Last modification date: 2023-10-18)
Primary citation	Brixius-Anderko, S.,Scott, E.E. Aldosterone Synthase Structure With Cushing Disease Drug LCI699 Highlights Avenues for Selective CYP11B Drug Design. Hypertension, 78:751-759, 2021 Cited by PubMed Abstract: [Figure: see text]. PubMed: 34247511 DOI: 10.1161/HYPERTENSIONAHA.121.17615 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.08 Å)

Structure validation