7LRE

Cryo-EM of the SLFN12-PDE3A complex: SLFN12 body refinement

Summary for 7LRE

• Entry DOI: 10.2210/pdb7lre/pdb
• Related: 7LRC 7LRD
• EMDB information: 23496
• Descriptor: Schlafen family member 12, ZINC ION (2 entities in total)
• Functional Keywords: complex, velcrin, molecular glue, dnmdp, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 134898.29

Authors

Fuller, J.R.,Garvie, C.W.,Lemke, C.T. (deposition date: 2021-02-16, release date: 2021-06-09, Last modification date: 2024-03-06)

• Primary citation: Garvie, C.W.,Wu, X.,Papanastasiou, M.,Lee, S.,Fuller, J.,Schnitzler, G.R.,Horner, S.W.,Baker, A.,Zhang, T.,Mullahoo, J.P.,Westlake, L.,Hoyt, S.H.,Toetzl, M.,Ranaghan, M.J.,de Waal, L.,McGaunn, J.,Kaplan, B.,Piccioni, F.,Yang, X.,Lange, M.,Tersteegen, A.,Raymond, D.,Lewis, T.A.,Carr, S.A.,Cherniack, A.D.,Lemke, C.T.,Meyerson, M.,Greulich, H.; Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.; Nat Commun, 12:4375-4375, 2021; PubMed: 34272366; DOI: 10.1038/s41467-021-24495-w

Experimental method

ELECTRON MICROSCOPY (2.76 Å)