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7LRD

Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model

Summary for 7LRD
Entry DOI10.2210/pdb7lrd/pdb
EMDB information23495
DescriptorSchlafen family member 12, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, ZINC ION, ... (6 entities in total)
Functional Keywordscomplex, velcrin, molecular glue, dnmdp, rna binding protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight250373.47
Authors
Fuller, J.R.,Garvie, C.W.,Lemke, C.T. (deposition date: 2021-02-16, release date: 2021-06-09, Last modification date: 2024-03-06)
Primary citationGarvie, C.W.,Wu, X.,Papanastasiou, M.,Lee, S.,Fuller, J.,Schnitzler, G.R.,Horner, S.W.,Baker, A.,Zhang, T.,Mullahoo, J.P.,Westlake, L.,Hoyt, S.H.,Toetzl, M.,Ranaghan, M.J.,de Waal, L.,McGaunn, J.,Kaplan, B.,Piccioni, F.,Yang, X.,Lange, M.,Tersteegen, A.,Raymond, D.,Lewis, T.A.,Carr, S.A.,Cherniack, A.D.,Lemke, C.T.,Meyerson, M.,Greulich, H.
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12:4375-4375, 2021
Cited by
PubMed: 34272366
DOI: 10.1038/s41467-021-24495-w
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.22 Å)
Structure validation

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