7LRD

Cryo-EM of the SLFN12-PDE3A complex: Consensus subset model

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Schlafen family member 12	polymer	583	67383.7	2	UniProt (Q8IYM2) Pfam (PF17057) Pfam (PF04326) Pfam (PF21026) In PDB	Homo sapiens (Human)
2	B, D	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	polymer	503	57353.0	2	UniProt (Q14432) Pfam (PF00233) In PDB	Homo sapiens (Human)	Cyclic GMP-inhibited phosphodiesterase A,CGI-PDE A
3	A, C	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	B, D	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
5	B, D	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	B, D	(4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one	non-polymer		305.4	2	Chemie (X5M)

Sequence modifications

A, C: 1 - 578 (UniProt: Q8IYM2)

PDB	External Database	Details
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

B, D: 640 - 1141 (UniProt: Q14432)

PDB	External Database	Details
Gly 639	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	249473.5
Non-Polymers*	Number of molecules	8
	Total formula weight	900.0
All*	Total formula weight	250373.5

*Water molecules are not included.