7LRC
Cryo-EM of the SLFN12-PDE3A complex: PDE3A body refinement
Summary for 7LRC
Entry DOI | 10.2210/pdb7lrc/pdb |
EMDB information | 23494 |
Descriptor | cGMP-inhibited 3',5'-cyclic phosphodiesterase A, Schlafen family member 12, MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | complex, velcrin, molecular glue, dnmdp, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 250242.65 |
Authors | Fuller, J.R.,Garvie, C.W.,Lemke, C.T. (deposition date: 2021-02-16, release date: 2021-06-09, Last modification date: 2024-03-06) |
Primary citation | Garvie, C.W.,Wu, X.,Papanastasiou, M.,Lee, S.,Fuller, J.,Schnitzler, G.R.,Horner, S.W.,Baker, A.,Zhang, T.,Mullahoo, J.P.,Westlake, L.,Hoyt, S.H.,Toetzl, M.,Ranaghan, M.J.,de Waal, L.,McGaunn, J.,Kaplan, B.,Piccioni, F.,Yang, X.,Lange, M.,Tersteegen, A.,Raymond, D.,Lewis, T.A.,Carr, S.A.,Cherniack, A.D.,Lemke, C.T.,Meyerson, M.,Greulich, H. Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. Nat Commun, 12:4375-4375, 2021 Cited by PubMed: 34272366DOI: 10.1038/s41467-021-24495-w PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.97 Å) |
Structure validation
Download full validation report