7LPX

Crystal Structure of HIV-1 RT in Complex with NBD-14270

Summary for 7LPX

Entry DOI	10.2210/pdb7lpx/pdb
Descriptor	Reverse transcriptase p66, Reverse transcriptase p51, SULFATE ION, ... (5 entities in total)
Functional Keywords	human immunodeficiency virus 1, non nucleotide-reverse transcriptase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Human immunodeficiency virus type 1 (HIV-1) More
Total number of polymer chains	2
Total formula weight	114895.46
Authors	Losada, N.,Ruiz, F.X.,Arnold, E. (deposition date: 2021-02-12, release date: 2021-11-17, Last modification date: 2023-10-18)
Primary citation	Losada, N.,Ruiz, F.X.,Curreli, F.,Gruber, K.,Pilch, A.,Das, K.,Debnath, A.K.,Arnold, E. HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites. J.Med.Chem., 64:16530-16540, 2021 Cited by PubMed: 34735153 DOI: 10.1021/acs.jmedchem.1c01104 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation