7LPX
Crystal Structure of HIV-1 RT in Complex with NBD-14270
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase p66 | polymer | 557 | 63989.2 | 1 | UniProt (P03366) | Human immunodeficiency virus type 1 (HIV-1) | |
| 2 | B (B) | Reverse transcriptase p51 | polymer | 429 | 50096.5 | 1 | UniProt (P03366) | Human immunodeficiency virus type 1 (HIV-1) | |
| 3 | C, D, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | E (A) | ~{N}-[(1~{S})-2-azanyl-1-[5-(hydroxymethyl)-1,3-thiazol-2-yl]ethyl]-3-methyl-5-[5-(trifluoromethyl)pyridin-2-yl]-1~{H}-pyrrole-2-carboxamide | non-polymer | 425.4 | 1 | Chemie (YB7) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 129 | Chemie (HOH) |
Sequence modifications
A: 1 - 555 (UniProt: P03366)
B: 1 - 428 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
| Val 0 | - | expression tag |
| Ala 172 | Lys 771 | engineered mutation |
| Ala 173 | Lys 772 | engineered mutation |
| Ser 280 | Cys 879 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Ser 280 | Cys 879 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 114085.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 809.7 | |
| All* | Total formula weight | 114895.5 |
