7LPS
Crystal structure of DDB1-CRBN-ALV1 complex bound to Helios (IKZF2 ZF2)
Summary for 7LPS
Entry DOI | 10.2210/pdb7lps/pdb |
Descriptor | DNA damage-binding protein 1, Protein cereblon, Zinc finger protein Helios, ... (5 entities in total) |
Functional Keywords | crbn, ddb1, ikzf2, alv, degradation, e3 ligase, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 703337.26 |
Authors | Nowak, R.P.,Fischer, E.S. (deposition date: 2021-02-12, release date: 2021-06-02, Last modification date: 2023-10-18) |
Primary citation | Wang, E.S.,Verano, A.L.,Nowak, R.P.,Yuan, J.C.,Donovan, K.A.,Eleuteri, N.A.,Yue, H.,Ngo, K.H.,Lizotte, P.H.,Gokhale, P.C.,Gray, N.S.,Fischer, E.S. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat.Chem.Biol., 17:711-717, 2021 Cited by PubMed: 34035522DOI: 10.1038/s41589-021-00802-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.78 Å) |
Structure validation
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