7LMM

Crystal structure of bovine DNMT1 BAH1 domain in complex with H4K20me2

Summary for 7LMM

• Entry DOI: 10.2210/pdb7lmm/pdb
• Related: 7LMK
• Descriptor: DNA (cytosine-5)-methyltransferase 1,DNA (cytosine-5)-methyltransferase 1, Histone H4, ZINC ION, ... (4 entities in total)
• Functional Keywords: dna methylation, dna methyltransferase 1, histone modification, allosteric regulation, transferase
• Biological source: Bos taurus (Bovine); More
• Total number of polymer chains: 8
• Total formula weight: 77932.81

Authors

Ren, W.,Song, J. (deposition date: 2021-02-05, release date: 2021-02-17, Last modification date: 2023-10-18)

• Primary citation: Ren, W.,Fan, H.,Grimm, S.A.,Kim, J.J.,Li, L.,Guo, Y.,Petell, C.J.,Tan, X.F.,Zhang, Z.M.,Coan, J.P.,Yin, J.,Kim, D.I.,Gao, L.,Cai, L.,Khudaverdyan, N.,Cetin, B.,Patel, D.J.,Wang, Y.,Cui, Q.,Strahl, B.D.,Gozani, O.,Miller, K.M.,O'Leary, S.E.,Wade, P.A.,Wang, G.G.,Song, J.; DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.; Nat Commun, 12:2490-2490, 2021; PubMed: 33941775; DOI: 10.1038/s41467-021-22665-4

Experimental method

X-RAY DIFFRACTION (2.798 Å)