7LBG

CryoEM structure of the HCMV Trimer gHgLgO in complex with human Transforming growth factor beta receptor type 3 and neutralizing fabs 13H11 and MSL-109

Summary for 7LBG

• Entry DOI: 10.2210/pdb7lbg/pdb
• EMDB information: 23254
• Descriptor: Envelope glycoprotein H, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: virus, receptor, complex, neutralizing antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human cytomegalovirus (strain Merlin) (HHV-5); More
• Total number of polymer chains: 8
• Total formula weight: 377522.25

Authors

Kschonsak, M.,Rouge, L.,Arthur, C.P.,Hoangdung, H.,Patel, N.,Kim, I.,Johnson, M.,Kraft, E.,Rohou, A.L.,Gill, A.,Martinez-Martin, N.,Payandeh, J.,Ciferri, C. (deposition date: 2021-01-07, release date: 2021-03-10, Last modification date: 2021-03-17)

• Primary citation: Kschonsak, M.,Rouge, L.,Arthur, C.P.,Hoangdung, H.,Patel, N.,Kim, I.,Johnson, M.C.,Kraft, E.,Rohou, A.L.,Gill, A.,Martinez-Martin, N.,Payandeh, J.,Ciferri, C.; Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry.; Cell, 184:1232-, 2021; PubMed: 33626330; DOI: 10.1016/j.cell.2021.01.036

Experimental method

ELECTRON MICROSCOPY (2.6 Å)