7L9A
Crystal structure of BRDT bromodomain 2 in complex with CDD-1102
Summary for 7L9A
Entry DOI | 10.2210/pdb7l9a/pdb |
Descriptor | Bromodomain testis-specific protein, N~1~-(5-{[3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carbonyl]amino}-2-methylphenyl)-N~4~-methylbenzene-1,4-dicarboxamide, BETA-MERCAPTOETHANOL, ... (4 entities in total) |
Functional Keywords | transcription/inhibitor, transcription-inhibitor complex |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 32801.59 |
Authors | Sharma, R.,Kaur, G.,Yu, Z.,Ku, A.F.,Anglin, J.L.,Ucisik, M.N.,Faver, J.C.,Sankaran, B.,Kim, C.,Matzuk, M.M. (deposition date: 2021-01-03, release date: 2021-06-30, Last modification date: 2023-10-18) |
Primary citation | Yu, Z.,Ku, A.F.,Anglin, J.L.,Sharma, R.,Ucisik, M.N.,Faver, J.C.,Li, F.,Nyshadham, P.,Simmons, N.,Sharma, K.L.,Nagarajan, S.,Riehle, K.,Kaur, G.,Sankaran, B.,Storl-Desmond, M.,Palmer, S.S.,Young, D.W.,Kim, C.,Matzuk, M.M. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33637650DOI: 10.1073/pnas.2021102118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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