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7L05

Complex of novel maytansinoid M24 bound to T2R-TTL (two tubulin alpha/beta heterodimers, RB3 stathmin-like domain, and tubulin tyrosine ligase)

Summary for 7L05
Entry DOI10.2210/pdb7l05/pdb
DescriptorTubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (14 entities in total)
Functional Keywordsmaytansinoid, tubulin, antibody-drug conjugate, structural protein
Biological sourceRattus norvegicus (Norway rat)
More
Total number of polymer chains6
Total formula weight266147.93
Authors
Franklin, M.C. (deposition date: 2020-12-11, release date: 2021-12-22, Last modification date: 2023-10-18)
Primary citationDaSilva, J.O.,Yang, K.,Surriga, O.,Nittoli, T.,Kunz, A.,Franklin, M.C.,Delfino, F.J.,Mao, S.,Zhao, F.,Giurleo, J.T.,Kelly, M.P.,Makonnen, S.,Hickey, C.,Krueger, P.,Foster, R.,Chen, Z.,Retter, M.W.,Slim, R.,Young, T.M.,Olson, W.C.,Thurston, G.,Daly, C.
A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade.
Mol.Cancer Ther., 20:1966-1976, 2021
Cited by
PubMed: 34315762
DOI: 10.1158/1535-7163.MCT-21-0009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.21 Å)
Structure validation

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