7L05
Complex of novel maytansinoid M24 bound to T2R-TTL (two tubulin alpha/beta heterodimers, RB3 stathmin-like domain, and tubulin tyrosine ligase)
Summary for 7L05
Entry DOI | 10.2210/pdb7l05/pdb |
Descriptor | Tubulin alpha-1B chain, GUANOSINE-5'-DIPHOSPHATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (14 entities in total) |
Functional Keywords | maytansinoid, tubulin, antibody-drug conjugate, structural protein |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 6 |
Total formula weight | 266147.93 |
Authors | Franklin, M.C. (deposition date: 2020-12-11, release date: 2021-12-22, Last modification date: 2023-10-18) |
Primary citation | DaSilva, J.O.,Yang, K.,Surriga, O.,Nittoli, T.,Kunz, A.,Franklin, M.C.,Delfino, F.J.,Mao, S.,Zhao, F.,Giurleo, J.T.,Kelly, M.P.,Makonnen, S.,Hickey, C.,Krueger, P.,Foster, R.,Chen, Z.,Retter, M.W.,Slim, R.,Young, T.M.,Olson, W.C.,Thurston, G.,Daly, C. A Biparatopic Antibody-Drug Conjugate to Treat MET-Expressing Cancers, Including Those that Are Unresponsive to MET Pathway Blockade. Mol.Cancer Ther., 20:1966-1976, 2021 Cited by PubMed: 34315762DOI: 10.1158/1535-7163.MCT-21-0009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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