7L05
Complex of novel maytansinoid M24 bound to T2R-TTL (two tubulin alpha/beta heterodimers, RB3 stathmin-like domain, and tubulin tyrosine ligase)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) In PDB | Sus scrofa (pig) | Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain |
2 | B, D | Tubulin beta chain | polymer | 445 | 49907.8 | 2 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) In PDB | Sus scrofa (pig) | Beta-tubulin |
3 | E | Stathmin-4 | polymer | 149 | 17673.0 | 1 | UniProt (P63043) Pfam (PF00836) In PDB | Rattus norvegicus (Norway rat) | Stathmin-like protein B3,RB3 |
4 | F | Tubulin Tyrosine Ligase | polymer | 384 | 44378.5 | 1 | UniProt (E1BQ43) In PDB | Gallus gallus (chicken) | |
5 | A, C | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
6 | A, B, C, D, F | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
7 | A, B, C | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
8 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
9 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
10 | B, D | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
11 | B | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
12 | D | (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-(methylamino)propanoyl]amino}propanoate (non-preferred name) | non-polymer | 735.3 | 1 | Chemie (XQ4) | |||
13 | F | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
14 | water | water | 18.0 | 957 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
F: 1 - 378 (UniProt: E1BQ43)
PDB | External Database | Details |
---|---|---|
Met 3 | - | initiating methionine |
Ala 4 | - | cloning artifact |
His 146 | - | expression tag |
His 147 | - | expression tag |
His 148 | - | expression tag |
His 149 | - | expression tag |
His 150 | - | expression tag |
His 151 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 379 | - | expression tag |
His 380 | - | expression tag |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 262276.0 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 3872.0 | |
All* | Total formula weight | 266147.9 |