7KFP

Structure of human PARG complexed with PARG-119

Summary for 7KFP

• Entry DOI: 10.2210/pdb7kfp/pdb
• Related: 7KG0 7KG1 7KG3 7KG6 7KG7 7KG8
• Descriptor: Poly(ADP-ribose) glycohydrolase, N-{[2-(1,3-dimethyl-2-oxo-6-sulfanylidene-1,2,3,6-tetrahydro-7H-purin-7-yl)ethyl]carbamoyl}methanesulfonamide, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: hydrolase, hydrolase inhibitor complex, methyl xanthine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 62031.33

Authors

Brosey, C.A.,Bommagani, S.,Warden, L.S.,Jones, D.E.,Ahmed, Z.,Tainer, J.A. (deposition date: 2020-10-14, release date: 2021-03-10, Last modification date: 2023-10-18)

• Primary citation: Brosey, C.A.,Houl, J.H.,Katsonis, P.,Balapiti-Modarage, L.P.F.,Bommagani, S.,Arvai, A.,Moiani, D.,Bacolla, A.,Link, T.,Warden, L.S.,Lichtarge, O.,Jones, D.E.,Ahmed, Z.,Tainer, J.A.; Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.; Prog.Biophys.Mol.Biol., 163:171-186, 2021; PubMed: 33636189; DOI: 10.1016/j.pbiomolbio.2021.02.002

Experimental method

X-RAY DIFFRACTION (1.9 Å)