7KFP
Structure of human PARG complexed with PARG-119
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Poly(ADP-ribose) glycohydrolase | polymer | 531 | 61020.4 | 1 | UniProt (Q86W56) Pfam (PF20811) Pfam (PF05028) In PDB | Homo sapiens (Human) | |
2 | A | N-{[2-(1,3-dimethyl-2-oxo-6-sulfanylidene-1,2,3,6-tetrahydro-7H-purin-7-yl)ethyl]carbamoyl}methanesulfonamide | non-polymer | 360.4 | 1 | Chemie (WD7) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | A | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
6 | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
A: 448 - 976 (UniProt: Q86W56)
PDB | External Database | Details |
---|---|---|
Gly 446 | - | expression tag |
Ser 447 | - | expression tag |
Ala 616 | Lys 616 | engineered mutation |
Ala 617 | Gln 617 | engineered mutation |
Ala 618 | Lys 618 | engineered mutation |
Ala 688 | Glu 688 | engineered mutation |
Ala 689 | Lys 689 | engineered mutation |
Ala 690 | Lys 690 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 61020.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1011.0 | |
All* | Total formula weight | 62031.3 |