7KFP

Structure of human PARG complexed with PARG-119

7KFP の概要

• エントリーDOI: 10.2210/pdb7kfp/pdb
• 関連するPDBエントリー: 7KG0 7KG1 7KG3 7KG6 7KG7 7KG8
• 分子名称: Poly(ADP-ribose) glycohydrolase, N-{[2-(1,3-dimethyl-2-oxo-6-sulfanylidene-1,2,3,6-tetrahydro-7H-purin-7-yl)ethyl]carbamoyl}methanesulfonamide, DIMETHYL SULFOXIDE, ... (6 entities in total)
• 機能のキーワード: hydrolase, hydrolase inhibitor complex, methyl xanthine, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 62031.33

構造登録者

Brosey, C.A.,Bommagani, S.,Warden, L.S.,Jones, D.E.,Ahmed, Z.,Tainer, J.A. (登録日: 2020-10-14, 公開日: 2021-03-10, 最終更新日: 2023-10-18)

• 主引用文献: Brosey, C.A.,Houl, J.H.,Katsonis, P.,Balapiti-Modarage, L.P.F.,Bommagani, S.,Arvai, A.,Moiani, D.,Bacolla, A.,Link, T.,Warden, L.S.,Lichtarge, O.,Jones, D.E.,Ahmed, Z.,Tainer, J.A.; Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.; Prog.Biophys.Mol.Biol., 163:171-186, 2021; PubMed: 33636189; DOI: 10.1016/j.pbiomolbio.2021.02.002

実験手法

X-RAY DIFFRACTION (1.9 Å)