7KDZ

Crystal structure of the bromodomain (BD) of human Bromodomain and PHD finger-containing Transcription Factor (BPTF) bound to TP-238

7KDZ の概要

• エントリーDOI: 10.2210/pdb7kdz/pdb
• 分子名称: Nucleosome-remodeling factor subunit BPTF, 1,2-ETHANEDIOL, 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl)propyl]pyrimidin-4-amine, ... (4 entities in total)
• 機能のキーワード: brd, phd, gene regulation, fac1, falz
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14976.06

構造登録者

Chan, A.,Schonbrunn, E. (登録日: 2020-10-09, 公開日: 2020-12-09, 最終更新日: 2023-10-18)

• 主引用文献: Ycas, P.D.,Zahid, H.,Chan, A.,Olson, N.M.,Johnson, J.A.,Talluri, S.K.,Schonbrunn, E.,Pomerantz, W.C.K.; New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development; Organic & Biomolecular Chemistry, 18(27):5174-5182, 2020; PubMed: 32588860; DOI: 10.1039/d0ob00506a

実験手法

X-RAY DIFFRACTION (1.54 Å)