7K9Q

Co-crystal structure of alpha glucosidase with compound 4

Summary for 7K9Q

Entry DOI	10.2210/pdb7k9q/pdb
Descriptor	Alpha glucosidase 2 alpha neutral subunit, Glucosidase 2 subunit beta, (1S,2S,3R,4S,5S)-5-amino-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, ... (10 entities in total)
Functional Keywords	alpha glucosidase ii, endoplasmic reticulum, hydrolase, inhibitor complex, hydrolase-inhibitor complex
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	4
Total formula weight	349238.55
Authors	Karade, S.S.,Mariuzza, R.A. (deposition date: 2020-09-29, release date: 2021-09-29, Last modification date: 2023-10-18)
Primary citation	Karade, S.S.,Hill, M.L.,Kiappes, J.L.,Manne, R.,Aakula, B.,Zitzmann, N.,Warfield, K.L.,Treston, A.M.,Mariuzza, R.A. N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity. J.Med.Chem., 64:18010-18024, 2021 Cited by PubMed: 34870992 DOI: 10.1021/acs.jmedchem.1c01377 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation