7K9Q

Co-crystal structure of alpha glucosidase with compound 4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process
A	0006491	biological_process	N-glycan processing
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0017177	cellular_component	glucosidase II complex
A	0030246	molecular_function	carbohydrate binding
A	0033919	molecular_function	glucan 1,3-alpha-glucosidase activity
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0090599	molecular_function	alpha-glucosidase activity
B	0001701	biological_process	in utero embryonic development
B	0001889	biological_process	liver development
B	0003723	molecular_function	RNA binding
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0006491	biological_process	N-glycan processing
B	0010977	biological_process	negative regulation of neuron projection development
B	0017177	cellular_component	glucosidase II complex
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0044877	molecular_function	protein-containing complex binding
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0005975	biological_process	carbohydrate metabolic process
C	0006491	biological_process	N-glycan processing
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0017177	cellular_component	glucosidase II complex
C	0030246	molecular_function	carbohydrate binding
C	0033919	molecular_function	glucan 1,3-alpha-glucosidase activity
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0090599	molecular_function	alpha-glucosidase activity
D	0001701	biological_process	in utero embryonic development
D	0001889	biological_process	liver development
D	0003723	molecular_function	RNA binding
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0006491	biological_process	N-glycan processing
D	0010977	biological_process	negative regulation of neuron projection development
D	0017177	cellular_component	glucosidase II complex
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0044877	molecular_function	protein-containing complex binding
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DDNMDGMVSlaEL

Chain	Residue	Details
B	ASP222-LEU234

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site_id	PS00129
Number of Residues	8
Details	GLYCOSYL_HYDROL_F31_1 Glycosyl hydrolases family 31 active site. YVWnDMNE

Chain	Residue	Details
A	TYR560-GLU567

---

site_id	PS00707
Number of Residues	31
Details	GLYCOSYL_HYDROL_F31_2 Glycosyl hydrolases family 31 signature 2. GADVGGFfknPepeLLvRWyqMGAYqPFfRA

Chain	Residue	Details
A	GLY667-ALA697

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:27462106, ECO:0007744|PDB:5HJO

Chain	Residue	Details
B	ASP49
B	ASP53
D	ASP49
D	ASP53

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	BINDING: BINDING => ECO:0000269|PubMed:27462106, ECO:0007744|PDB:5F0E, ECO:0007744|PDB:5H9O, ECO:0007744|PDB:5HJO, ECO:0007744|PDB:5HJR, ECO:0007744|PDB:5IED, ECO:0007744|PDB:5IEE, ECO:0007744|PDB:5IEF, ECO:0007744|PDB:5IEG

Chain	Residue	Details
B	GLN50
B	ASP104
B	GLU105
D	GLN50
D	TYR55
D	ASP57
D	ASP63
D	GLU64
D	ARG91
D	ASP94
D	VAL96
B	TYR55
D	ASP98
D	ASP104
D	GLU105
B	ASP57
B	ASP63
B	GLU64
B	ARG91
B	ASP94
B	VAL96
B	ASP98

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
B	ASP222
D	GLU233
B	ASN224
B	ASP226
B	MET228
B	GLU233
D	ASP222
D	ASN224
D	ASP226
D	MET228

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P14314

Chain	Residue	Details
B	SER24
B	SER168
D	SER24
D	SER168

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000255

Chain	Residue	Details
B	SER89
B	SER376
B	SER383
B	SER427
D	SER89
D	SER376
D	SER383
D	SER427

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
B	LYS166
D	LYS166

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN72
B	ASN469
D	ASN72
D	ASN469

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