7K9Q
Co-crystal structure of alpha glucosidase with compound 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Alpha glucosidase 2 alpha neutral subunit | polymer | 977 | 110654.1 | 2 | UniProt (A1A4T2) | Mus musculus (Mouse) | Neutral alpha-glucosidase AB |
| 2 | B, D (B, D) | Glucosidase 2 subunit beta | polymer | 547 | 61451.5 | 2 | UniProt (O08795) Pfam (PF12999) Pfam (PF13202) Pfam (PF07915) | Mus musculus (Mouse) | 80K-H protein,Glucosidase II subunit beta,Protein kinase C substrate 60.1 kDa protein heavy chain,PKCSH |
| 3 | E, QA (A, C) | (1S,2S,3R,4S,5S)-5-amino-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol | non-polymer | 193.2 | 2 | Chemie (W9S) PubChem (54386254) PubChem (174312) PubChem (73357569) PubChem (101538062) PubChem (101540195) PubChem (102505498) PubChem (102505499) PubChem (9990176) PubChem (124427908) PubChem (13137289) PubChem (13137290) PubChem (13137297) PubChem (13137298) PubChem (124784701) PubChem (124784702) PubChem (124784703) PubChem (143936278) PubChem (162849025) PubChem (162849026) PubChem (162849027) PubChem (162849028) PubChem (171395627) | |||
| 4 | AB, CA, F, HB, K... (C, A, D) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 10 | Chemie (PEG) PubChem (8117) | |||
| 5 | G, M, MA, SA (A, B, C) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 4 | Chemie (PGE) | |||
| 6 | AA, BA, BB, CB, DA... (A, C, B, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 33 | Chemie (EDO) | |||
| 7 | FA, FB, GA, GB, HA... (A, C) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 8 | IB, JB, KA, LA (D, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 9 | KB (D) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) PubChem (8200) | |||
| 10 | MB, NB, OB, PB (A, B, C, D) | water | water | 18.0 | 871 | Chemie (HOH) |
Sequence modifications
A, C: 33 - 966 (UniProt: A1A4T2)
B, D: 15 - 517 (UniProt: O08795)
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
| Gly 3 | - | expression tag |
| Ile 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Pro 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Pro 8 | - | expression tag |
| Gly 9 | - | expression tag |
| Met 10 | - | expression tag |
| Pro 11 | - | expression tag |
| Ala 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Ser 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Val 17 | - | expression tag |
| Ser 18 | - | expression tag |
| Leu 19 | - | expression tag |
| Leu 20 | - | expression tag |
| Ser 21 | - | expression tag |
| Val 22 | - | expression tag |
| Leu 23 | - | expression tag |
| Leu 24 | - | expression tag |
| Met 25 | - | expression tag |
| Gly 26 | - | expression tag |
| Cys 27 | - | expression tag |
| Val 28 | - | expression tag |
| Ala 29 | - | expression tag |
| Glu 30 | - | expression tag |
| Thr 31 | - | expression tag |
| Gly 32 | - | expression tag |
| Asp 97 | Asn 97 | engineered mutation |
| Ser 967 | - | expression tag |
| Ala 968 | - | expression tag |
| Trp 969 | - | expression tag |
| Ser 970 | - | expression tag |
| His 971 | - | expression tag |
| Pro 972 | - | expression tag |
| Gln 973 | - | expression tag |
| Phe 974 | - | expression tag |
| Glu 975 | - | expression tag |
| Lys 976 | - | expression tag |
| Leu 977 | - | expression tag |
| Glu 978 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -16 | - | initiating methionine |
| Gly -15 | - | expression tag |
| Ile -14 | - | expression tag |
| Leu -13 | - | expression tag |
| Pro -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Pro -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Met -8 | - | expression tag |
| Pro -7 | - | expression tag |
| Ala -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Val -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 1 | - | expression tag |
| Leu 2 | - | expression tag |
| Ser 3 | - | expression tag |
| Val 4 | - | expression tag |
| Leu 5 | - | expression tag |
| Leu 6 | - | expression tag |
| Met 7 | - | expression tag |
| Gly 8 | - | expression tag |
| Cys 9 | - | expression tag |
| Val 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Glu 12 | - | expression tag |
| Thr 13 | - | expression tag |
| Gly 14 | - | expression tag |
| Ser 518 | - | expression tag |
| Ala 519 | - | expression tag |
| Trp 520 | - | expression tag |
| Leu 521 | - | expression tag |
| Glu 522 | - | expression tag |
| Thr 523 | - | expression tag |
| Lys 524 | - | expression tag |
| His 525 | - | expression tag |
| His 526 | - | expression tag |
| His 527 | - | expression tag |
| His 528 | - | expression tag |
| His 529 | - | expression tag |
| His 530 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 344211.1 | |
| Non-Polymers* | Number of molecules | 60 |
| Total formula weight | 5027.4 | |
| All* | Total formula weight | 349238.5 |
