7K66
Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor
Summary for 7K66
Entry DOI | 10.2210/pdb7k66/pdb |
Related | 6MF0 |
Descriptor | Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII, 2A9 heavy chain, 2A9 light chain, ... (10 entities in total) |
Functional Keywords | antibody, inhibitor, blood clotting, blood clotting-immune system complex, blood clotting/immune system |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 3 |
Total formula weight | 217290.01 |
Authors | Childers, K.C.,Gish, J.,Jarvis, L.,Peters, S.,Garrels, C.,Smith, I.W.,Spencer, H.T.,Spiegel, P.C. (deposition date: 2020-09-18, release date: 2020-10-14, Last modification date: 2023-10-18) |
Primary citation | Gish, J.S.,Jarvis, L.,Childers, K.C.,Peters, S.C.,Garrels, C.S.,Smith, I.W.,Spencer, H.T.,Doering, C.B.,Lollar, P.,Spiegel, P.C. Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor. Blood, 137:2981-2986, 2021 Cited by PubMed: 33529335DOI: 10.1182/blood.2020008940 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.92 Å) |
Structure validation
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