7K66

Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS00079
Number of Residues	21
Details	MULTICOPPER_OXIDASE1 Multicopper oxidases signature 1. GqFlLfChISshHhGGMeahV

Chain	Residue	Details
A	GLY305-VAL325
A	GLY686-LEU706
A	GLY1994-PHE2014

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
C	TYR191-HIS197

---

site_id	PS01285
Number of Residues	28
Details	FA58C_1 Coagulation factors 5/8 type C domain (FA58C) signature 1. AWstkepfs........WIkVDllapmiIhgIkTQG

Chain	Residue	Details
A	ALA2061-GLY2088
A	ALA2218-GLY2247

---

site_id	PS01286
Number of Residues	17
Details	FA58C_2 Coagulation factors 5/8 type C domain (FA58C) signature 2. Pthysirst..LRmELmGC

Chain	Residue	Details
A	PRO2153-CYS2169
A	PRO2310-CYS2326

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	174
Details	Domain: {"description":"Plastocyanin-like 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	148
Details	Domain: {"description":"F5/8 type C 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	152
Details	Domain: {"description":"F5/8 type C 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Cleavage; by thrombin","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---