7K66

Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII	polymer	1467	168287.0	1	UniProt (P12263) UniProt (P00451) Pfam (PF07732) Pfam (PF00394) Pfam (PF07731) Pfam (PF00754) In PDB	Sus scrofa (Pig)	Procoagulant component,Antihemophilic factor,AHF,Procoagulant component,Procoagulant component,Antihemophilic factor,AHF,Procoagulant component
2	B	2A9 heavy chain	polymer	223	23979.8	1		Mus musculus
3	C	2A9 light chain	polymer	213	23297.7	1		Mus musculus
4	H	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
5	D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
7	A	COPPER (II) ION	non-polymer		63.5	1	Chemie (CU)
8	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
9	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
10		water	water		18.0	1	Chemie (HOH)

Sequence modifications

A: -18 - 386 (UniProt: P12263)
A: 387 - 1626 (UniProt: P00451)
A: 1637 - 2019 (UniProt: P12263)
A: 2020 - 2332 (UniProt: P00451)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.