7K66

Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody Inhibitor

7K66 の概要

• エントリーDOI: 10.2210/pdb7k66/pdb
• 関連するPDBエントリー: 6MF0
• 分子名称: Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII,Coagulation factor VIII, 2A9 heavy chain, 2A9 light chain, ... (10 entities in total)
• 機能のキーワード: antibody, inhibitor, blood clotting, blood clotting-immune system complex, blood clotting/immune system
• 由来する生物種: Sus scrofa (Pig); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 217290.01

構造登録者

Childers, K.C.,Gish, J.,Jarvis, L.,Peters, S.,Garrels, C.,Smith, I.W.,Spencer, H.T.,Spiegel, P.C. (登録日: 2020-09-18, 公開日: 2020-10-14, 最終更新日: 2023-10-18)

• 主引用文献: Gish, J.S.,Jarvis, L.,Childers, K.C.,Peters, S.C.,Garrels, C.S.,Smith, I.W.,Spencer, H.T.,Doering, C.B.,Lollar, P.,Spiegel, P.C.; Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody inhibitor.; Blood, 137:2981-2986, 2021; PubMed: 33529335; DOI: 10.1182/blood.2020008940

実験手法

X-RAY DIFFRACTION (3.92 Å)