7JZ0

Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH).

Summary for 7JZ0

• Entry DOI: 10.2210/pdb7jz0/pdb
• Descriptor: 2'-O-methyltransferase, Non-structural protein 10, RNA (5'-D(*(M7G))-R(P*(A2M)P*UP*U)-3'), ... (9 entities in total)
• Functional Keywords: structural genomics, center for structural genomics of infectious diseases, csgid, nsp16, nsp10, complex, viral protein, sah, cap-1, viral protein-rna complex, viral protein/rna
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 6
• Total formula weight: 103536.76

Authors

Minasov, G.,Shuvalova, L.,Rosas-Lemus, M.,Kiryukhina, O.,Brunzelle, J.S.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-09-01, release date: 2020-09-16, Last modification date: 2026-04-01)

• Primary citation: Minasov, G.,Rosas-Lemus, M.,Shuvalova, L.,Inniss, N.L.,Brunzelle, J.S.,Daczkowski, C.M.,Hoover, P.,Mesecar, A.D.,Satchell, K.J.F.; Mn2+ coordinates Cap-0-RNA to align substrates for efficient 2'-O-methyl transfer by SARS-CoV-2 nsp16; Biorxiv, 2021; DOI: 10.1101/2021.01.31.429023

Experimental method

X-RAY DIFFRACTION (2.15 Å)