7JZ0

Crystal Structure of SARS-CoV-2 Nsp16/10 Heterodimer in Complex with (m7GpppA2m)pUpUpApApA (Cap-1) and S-Adenosyl-L-homocysteine (SAH).

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	2'-O-methyltransferase	polymer	300	33556.4	2	UniProt (P0DTD1) Pfam (PF06460) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NSP16
2	B, D	Non-structural protein 10	polymer	141	15004.1	2	UniProt (P0DTD1) Pfam (PF09401) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	NSP10
3	E, F	RNA (5'-D(*(M7G))-R(P*(A2M)P*UP*U)-3')	polymer	7	2338.4	2		Severe acute respiratory syndrome coronavirus 2
4	A, C	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
5	A, C	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
6	C, A	CHLORIDE ION	non-polymer		35.5	7	Chemie (CL)
7	C, A, B	FORMIC ACID	non-polymer		46.0	8	Chemie (FMT)
8	D, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
9		water	water		18.0	393	Chemie (HOH)

Sequence modifications

A, C: 6799 - 7096 (UniProt: P0DTD1)

PDB	External Database	Details
Ser 6797	-	expression tag
Asn 6798	-	expression tag

B, D: 4254 - 4392 (UniProt: P0DTD1)

PDB	External Database	Details
Ser 4252	-	expression tag
Asn 4253	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	101798.0
Non-Polymers*	Number of molecules	25
	Total formula weight	1738.8
All*	Total formula weight	103536.8

*Water molecules are not included.