7JTT

The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A in complex F9 inhibitor at the alpha-site and cesium ion at the metal coordination site. The single beta-Q114 rotamer conformation allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring

7JTT の概要

• エントリーDOI: 10.2210/pdb7jtt/pdb
• 関連するPDBエントリー: 6XE3 6XSY 7JHW 7JLL 7JMQ 7JQW
• 分子名称: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (10 entities in total)
• 機能のキーワード: lyase, inhibitor complex, tryptophan synthase, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75124.52

構造登録者

Hilario, E.,Dunn, M.F.,Mueller, L.J. (登録日: 2020-08-18, 公開日: 2021-08-25, 最終更新日: 2023-10-18)

• 主引用文献: Hilario, E.,Dunn, M.F.,Mueller, L.J.; The external aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A in complex F9 inhibitor at the alpha-site and cesium ion at the metal coordination site. The single beta-Q114 rotamer conformation allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring.; To be Published,

実験手法

X-RAY DIFFRACTION (1.64 Å)