7JLL

The internal aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A in complex with inhibitor 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (F9F) at the alpha-site, Cesium ion at the metal coordination site and L-Tryptophan at the enzyme beta-site

Summary for 7JLL

• Entry DOI: 10.2210/pdb7jll/pdb
• Related: 5CGQ 6XE3 6XSY 7JHW
• Descriptor: Tryptophan synthase alpha chain, 1,2-ETHANEDIOL, Tryptophan synthase beta chain, ... (11 entities in total)
• Functional Keywords: lyase, inhibitor complex, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720); More
• Total number of polymer chains: 2
• Total formula weight: 76004.14

Authors

Hilario, E.,Dunn, M.F.,Mueller, L.J. (deposition date: 2020-07-29, release date: 2021-08-04, Last modification date: 2023-10-18)

• Primary citation: Hilario, E.,Mueller, L.J.,Dunn, M.F.; The internal aldimine crystal structure of Salmonella typhimurium Tryptophan Synthase mutant beta-S377A in complex with inhibitor 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate (F9F) at the alpha-site, Cesium ion at the metal coordination site and L-Tryptophan at the enzyme beta-site.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)