7JMQ
The external aldimine form of the mutant beta-S377A Salmonella thypi tryptophan synthase in open conformation showing dual side chain conformations for the residue beta-Q114, sodium ion at the metal coordination site, and F9 inhibitor at the alpha-site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring
Summary for 7JMQ
Entry DOI | 10.2210/pdb7jmq/pdb |
Related | 6DZ4 6DZO 6WDU 6XSY |
Descriptor | Tryptophan synthase alpha chain, CHLORIDE ION, Tryptophan synthase beta chain, ... (11 entities in total) |
Functional Keywords | protein complex, lyase, f9f, internal aldimine |
Biological source | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) More |
Total number of polymer chains | 2 |
Total formula weight | 75512.08 |
Authors | Hilario, E.,Dunn, M.F.,Mueller, L.J. (deposition date: 2020-08-02, release date: 2021-08-04, Last modification date: 2023-10-18) |
Primary citation | Hilario, E.,Dunn, M.F.,Mueller, L.J. The external aldimine form of mutant beta-S377A Salmonella thypi tryptophan synthase in open conformation showing dual side chain conformations for the residue beta-Q114, sodium ion at the metal coordination site, and F9 inhibitor at the alpha-site. One of the beta-Q114 rotamer conformations allows a hydrogen bond to form with the PLP oxygen at the position 3 in the ring. To be Published, |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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