7JL0
Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer)
Summary for 7JL0
Entry DOI | 10.2210/pdb7jl0/pdb |
EMDB information | 22368 22369 22370 22371 |
Descriptor | RNA (5'-R(P*GP*AP*CP*UP*GP*AP*CP*UP*GP*AP*CP*UP*GP*A)-3'), RNA (5'-R(P*UP*CP*AP*GP*UP*CP*AP*GP*UP*CP*AP*GP*UP*C)-3'), Interferon-induced helicase C domain-containing protein 1, ... (8 entities in total) |
Functional Keywords | innate immunity, ubiquitin e3 ligase, dsrna, rna helicase, trim family, hydrolase-immune system-rna complex, hydrolase/immune system/rna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 116075.35 |
Authors | |
Primary citation | Kato, K.,Ahmad, S.,Zhu, Z.,Young, J.M.,Mu, X.,Park, S.,Malik, H.S.,Hur, S. Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Mol.Cell, 81:599-613.e8, 2021 Cited by PubMed: 33373584DOI: 10.1016/j.molcel.2020.11.047 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.3 Å) |
Structure validation
Download full validation report