7JL0

Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer)

Summary for 7JL0

• Entry DOI: 10.2210/pdb7jl0/pdb
• EMDB information: 22368 22369 22370 22371
• Descriptor: RNA (5'-R(P*GP*AP*CP*UP*GP*AP*CP*UP*GP*AP*CP*UP*GP*A)-3'), RNA (5'-R(P*UP*CP*AP*GP*UP*CP*AP*GP*UP*CP*AP*GP*UP*C)-3'), Interferon-induced helicase C domain-containing protein 1, ... (8 entities in total)
• Functional Keywords: innate immunity, ubiquitin e3 ligase, dsrna, rna helicase, trim family, hydrolase-immune system-rna complex, hydrolase/immune system/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 116075.35

Authors

Kato, K.,Ahmad, S.,Hur, S. (deposition date: 2020-07-29, release date: 2020-12-09, Last modification date: 2024-03-06)

• Primary citation: Kato, K.,Ahmad, S.,Zhu, Z.,Young, J.M.,Mu, X.,Park, S.,Malik, H.S.,Hur, S.; Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.; Mol.Cell, 81:599-613.e8, 2021; PubMed: 33373584; DOI: 10.1016/j.molcel.2020.11.047

Experimental method

ELECTRON MICROSCOPY (4.3 Å)