7JL0
Cryo-EM structure of MDA5-dsRNA in complex with TRIM65 PSpry domain (Monomer)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | X | RNA (5'-R(P*GP*AP*CP*UP*GP*AP*CP*UP*GP*AP*CP*UP*GP*A)-3') | polymer | 14 | 4486.7 | 1 | Homo sapiens | ||
2 | Y | RNA (5'-R(P*UP*CP*AP*GP*UP*CP*AP*GP*UP*CP*AP*GP*UP*C)-3') | polymer | 14 | 4423.7 | 1 | Homo sapiens | ||
3 | A | Interferon-induced helicase C domain-containing protein 1 | polymer | 739 | 84901.7 | 1 | UniProt (Q9BYX4) Pfam (PF04851) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) In PDB | Homo sapiens (Human) | Clinically amyopathic dermatomyositis autoantigen 140 kDa,CADM-140 autoantigen,Helicase with 2 CARD domains,Helicard,Interferon-induced with helicase C domain protein 1,Melanoma differentiation-associated protein 5,MDA-5,Murabutide down-regulated protein,RIG-I-like receptor 2,RLR-2,RNA helicase-DEAD box protein 116,IFIH1 |
4 | B | Tripartite motif-containing protein 65 | polymer | 191 | 21643.4 | 1 | UniProt (Q6PJ69) Pfam (PF00622) In PDB | Homo sapiens (Human) | TRIM65 |
5 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
6 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
7 | A | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 1 | Chemie (ALF) | |||
8 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 287 - 1025 (UniProt: Q9BYX4)
B: 312 - 502 (UniProt: Q6PJ69)
PDB | External Database | Details |
---|---|---|
Arg 843 | His 843 | conflict |
Lys 944 | Asn 944 | conflict |
Thr 946 | Ala 946 | conflict |
PDB | External Database | Details |
---|---|---|
Leu 356 | Cys 356 | conflict |
Ser 407 | Cys 407 | conflict |
Ser 421 | Cys 421 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 115455.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 619.9 | |
All* | Total formula weight | 116075.3 |