7JHD

Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with TTC-352 and GRIP Peptide

Summary for 7JHD

Entry DOI	10.2210/pdb7jhd/pdb
Descriptor	Estrogen receptor, Nuclear receptor coactivator 2, 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophene-6-ol, ... (4 entities in total)
Functional Keywords	breast cancer, synthetic agonist, drug resistance, apoptosis, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	61007.81
Authors	Fanning, S.W.,Abderraman, B.,Maximov, P.Y.,Jordan, V.C.,Greene, G.L. (deposition date: 2020-07-20, release date: 2020-11-25, Last modification date: 2023-10-18)
Primary citation	Abderrahman, B.,Maximov, P.Y.,Curpan, R.F.,Fanning, S.W.,Hanspal, J.S.,Fan, P.,Foulds, C.E.,Chen, Y.,Malovannaya, A.,Jain, A.,Xiong, R.,Greene, G.L.,Tonetti, D.A.,Thatcher, G.R.J.,Jordan, V.C. Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer. Mol.Cancer Ther., 20:11-25, 2021 Cited by PubMed: 33177154 DOI: 10.1158/1535-7163.MCT-20-0563 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.402 Å)

Structure validation