7JHD
Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with TTC-352 and GRIP Peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue V9J A 601 |
| Chain | Residue |
| A | THR347 |
| A | ILE424 |
| A | HIS524 |
| A | LEU525 |
| A | HOH706 |
| A | GLU353 |
| A | LEU384 |
| A | LEU387 |
| A | MET388 |
| A | LEU391 |
| A | ARG394 |
| A | PHE404 |
| A | MET421 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue V9J B 601 |
| Chain | Residue |
| B | LEU346 |
| B | THR347 |
| B | GLU353 |
| B | LEU384 |
| B | LEU387 |
| B | MET388 |
| B | LEU391 |
| B | ARG394 |
| B | PHE404 |
| B | MET421 |
| B | ILE424 |
| B | HIS524 |
| B | LEU525 |
| B | HOH713 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| A | ARG394 | |
| A | HIS524 | |
| B | GLU353 | |
| B | ARG394 | |
| B | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | SER537 | |
| B | SER537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 | |
| B | CYS447 |
