7JHD
Estrogen Receptor Alpha Ligand Binding Domain Y537S in Complex with TTC-352 and GRIP Peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 251 | 28571.7 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) | Homo sapiens (Human) | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | E, F (A, B) | 3-(4-fluorophenyl)-2-(4-hydroxyphenoxy)-1-benzothiophene-6-ol | non-polymer | 352.4 | 2 | Chemie (V9J) | |||
| 4 | G, H, I (A, B, C) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A, B: 305 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Met 304 | - | initiating methionine |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60303.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 704.8 | |
| All* | Total formula weight | 61007.8 |
