7F3O

Crystal structure of the GluA2o LBD in complex with glutamate and TAK-653

7F3O の概要

• エントリーDOI: 10.2210/pdb7f3o/pdb
• 分子名称: Glutamate receptor 2, GLUTAMIC ACID, 7-(4-cyclohexyloxyphenyl)-9-methyl-4$l^{6}-thia-1$l^{4},5,8-triazabicyclo[4.4.0]deca-1(10),6,8-triene 4,4-dioxide, ... (7 entities in total)
• 機能のキーワード: ampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 179104.62

構造登録者

Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (登録日: 2021-06-16, 公開日: 2021-07-28, 最終更新日: 2023-11-29)

• 主引用文献: Suzuki, A.,Kunugi, A.,Tajima, Y.,Suzuki, N.,Suzuki, M.,Toyofuku, M.,Kuno, H.,Sogabe, S.,Kosugi, Y.,Awasaki, Y.,Kaku, T.,Kimura, H.; Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement.; Sci Rep, 11:14532-14532, 2021; PubMed: 34267258; DOI: 10.1038/s41598-021-93888-0

実験手法

X-RAY DIFFRACTION (1.44 Å)