7EX8

Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 27

Summary for 7EX8

Entry DOI	10.2210/pdb7ex8/pdb
Descriptor	Replicase, MANGANESE (II) ION, methyl (Z)-4-[1-[(3-chlorophenyl)methyl]-4-[(4-chlorophenyl)methyl]piperidin-4-yl]-2-oxidanyl-4-oxidanylidene-but-2-enoate, ... (5 entities in total)
Functional Keywords	endonuclease, hydrolase
Biological source	Abbey lake orthobunyavirus
Total number of polymer chains	1
Total formula weight	25860.48
Authors	Kuang, W.,Hu, Z.,Gong, P. (deposition date: 2021-05-26, release date: 2022-02-16, Last modification date: 2023-11-29)
Primary citation	Kuang, W.,Zhang, H.,Cai, Y.,Zhang, G.,Deng, F.,Li, H.,Zhou, Y.,Wang, M.,Gong, P.,Guo, Y.,Hu, Z. Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales ). J.Virol., 96:e0217321-e0217321, 2022 Cited by PubMed: 35266805 DOI: 10.1128/jvi.02173-21 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation