7EQF

Crystal Structure of a Transcription Factor in complex with Ligand

Summary for 7EQF

• Entry DOI: 10.2210/pdb7eqf/pdb
• Related: 7EQE
• Descriptor: TetR/AcrR family transcriptional regulator, (6~{R})-3-methyl-8-[(2~{S},4~{R},5~{S},6~{R})-6-methyl-5-[(2~{S},4~{R},5~{R},6~{R})-6-methyl-4-[(2~{S},5~{S},6~{S})-6-methyl-5-[(2~{S},4~{R},5~{S},6~{R})-6-methyl-5-[(2~{S},4~{S},5~{S},6~{R})-6-methyl-4-[(2~{S},5~{S},6~{S})-6-methyl-5-oxidanyl-oxan-2-yl]oxy-5-oxidanyl-oxan-2-yl]oxy-4-oxidanyl-oxan-2-yl]oxy-oxan-2-yl]oxy-5-oxidanyl-oxan-2-yl]oxy-4-oxidanyl-oxan-2-yl]oxy-1,6,11-tris(oxidanyl)-5,6-dihydrobenzo[a]anthracene-7,12-dione (2 entities in total)
• Functional Keywords: transcription factor, transcription
• Biological source: Streptomyces griseoluteus
• Total number of polymer chains: 4
• Total formula weight: 92603.19

Authors

Uehara, S.,Tsugita, A.,Matsui, T.,Yokoyama, T.,Ostash, I.,Ostash, B.,Tanaka, Y. (deposition date: 2021-05-01, release date: 2022-04-27, Last modification date: 2023-11-29)

• Primary citation: Tsugita, A.,Uehara, S.,Matsui, T.,Yokoyama, T.,Ostash, I.,Deneka, M.,Yalamanchili, S.,Bennett, C.S.,Tanaka, Y.,Ostash, B.; The carbohydrate tail of landomycin A is responsible for its interaction with the repressor protein LanK.; Febs J., 289:6038-6057, 2022; PubMed: 35429224; DOI: 10.1111/febs.16460

Experimental method

X-RAY DIFFRACTION (2.91 Å)