7EHV
Human MTHFD2 in complex with compound 21 and 3
Summary for 7EHV
Entry DOI | 10.2210/pdb7ehv/pdb |
Related | 7EHJ 7EHM 7EHN |
Descriptor | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, 1-(3,4-dichlorobenzyl)-8-(((1R,4R)-4-hydroxycyclohexyl)amino)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione, (2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid, ... (4 entities in total) |
Functional Keywords | mthfd2, methylenetetrahydrofolate dehydrogenase 2, 1c metabolism, mitocondria, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 70108.50 |
Authors | Lee, L.C.,Peng, Y.H.,Wu, S.Y. (deposition date: 2021-03-30, release date: 2021-08-11, Last modification date: 2023-11-29) |
Primary citation | Lee, L.C.,Peng, Y.H.,Chang, H.H.,Hsu, T.,Lu, C.T.,Huang, C.H.,Hsueh, C.C.,Kung, F.C.,Kuo, C.C.,Jiaang, W.T.,Wu, S.Y. Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2). J.Med.Chem., 64:11288-11301, 2021 Cited by PubMed: 34337952DOI: 10.1021/acs.jmedchem.1c00663 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.61 Å) |
Structure validation
Download full validation report