7EHV

Human MTHFD2 in complex with compound 21 and 3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	polymer	315	34183.6	2	UniProt (P13995) Pfam (PF00763) Pfam (PF02882) In PDB	Homo sapiens (Human)
2	A, B	1-(3,4-dichlorobenzyl)-8-(((1R,4R)-4-hydroxycyclohexyl)amino)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione	non-polymer		452.3	2	Chemie (J4L)
3	A, B	(2S)-2-[[4-[(4-azanyl-6-oxidanyl-pyrimidin-5-yl)carbamoylamino]phenyl]carbonylamino]pentanedioic acid	non-polymer		418.4	2	Chemie (J49)
4		water	water		18.0	22	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68367.1
Non-Polymers*	Number of molecules	4
	Total formula weight	1741.4
All*	Total formula weight	70108.5

*Water molecules are not included.