7EDZ

Crystal Structure of human PPCS in complex with P-HoPan and AMPPNP

Summary for 7EDZ

• Entry DOI: 10.2210/pdb7edz/pdb
• Descriptor: Phosphopantothenate--cysteine ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... (7 entities in total)
• Functional Keywords: phosphopantothenoylcysteine synthetase, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 140840.25

Authors

Sharma, N.,Mostert, K.J.,Strauss, E.,Anand, R. (deposition date: 2021-03-17, release date: 2021-11-24, Last modification date: 2023-11-29)

• Primary citation: Mostert, K.J.,Sharma, N.,van der Zwaag, M.,Staats, R.,Koekemoer, L.,Anand, R.,Sibon, O.C.M.,Strauss, E.; The Coenzyme A Level Modulator Hopantenate (HoPan) Inhibits Phosphopantotenoylcysteine Synthetase Activity.; Acs Chem.Biol., 16:2401-2414, 2021; PubMed: 34582681; DOI: 10.1021/acschembio.1c00535

Experimental method

X-RAY DIFFRACTION (1.95 Å)