7EDZ
Crystal Structure of human PPCS in complex with P-HoPan and AMPPNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (D, C, B, A) | Phosphopantothenate--cysteine ligase | polymer | 311 | 34035.1 | 4 | UniProt (Q9HAB8) Pfam (PF04127) | Homo sapiens (Human) | Phosphopantothenoylcysteine synthetase,PPC synthetase |
| 2 | E, K, Q, X (D, C, B, A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 4 | Chemie (ANP) | |||
| 3 | CA, DA, F, H, J... (A, D, C, B) | SULFATE ION | non-polymer | 96.1 | 9 | Chemie (SO4) | |||
| 4 | G, M, S, Z (D, C, B, A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | I, L, R, Y (D, C, B, A) | 4-[[(2R)-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]butanoic acid | non-polymer | 313.2 | 4 | Chemie (J1O) | |||
| 6 | AA, BA, P, U, V (A, C, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 7 | EA, FA, GA, HA (D, C, B, A) | water | water | 18.0 | 453 | Chemie (HOH) |
Sequence modifications
D, C, B, A: 1 - 311 (UniProt: Q9HAB8)
| PDB | External Database | Details |
|---|---|---|
| Val 146 | Ala 146 | variant |
| Leu 268 | Phe 268 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 136140.2 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 4700.0 | |
| All* | Total formula weight | 140840.3 |
