7ECA

Crystal structure of the Keap1 complex with a peptide base on ETGE motif.

Summary for 7ECA

• Entry DOI: 10.2210/pdb7eca/pdb
• Descriptor: Kelch-like ECH-associated protein 1, LEU-ASP-GLU-GLU-THR-GLY-GLU-PHE-LEU-PRO, SULFATE ION, ... (4 entities in total)
• Functional Keywords: nrf2, oxidative stress, cancer, cytosolic protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 40821.12

Authors

Cheng, L.,Wang, C. (deposition date: 2021-03-11, release date: 2022-03-16, Last modification date: 2023-11-29)

Primary citation

Cheng, L.,Wang, H.,Li, S.,Liu, Z.,Wang, C.
New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations.
Life Sci, 282:119791-119791, 2021

PubMed Abstract: Keap1-Nrf2 signaling pathway is one of the most important antioxidant signaling pathways, and its abnormal activation is related to cancer metastasis and drug resistance. Many studies have shown Keap1 and Nrf2 mutations are closely associated with cancer occurrence. However, few studies focus on Keap1-Nrf2 binding characteristics of cancer-associated mutations. The study investigated the molecular mechanism between Keap1/Nrf2 mutations and cancer.

PubMed: 34229009
DOI: 10.1016/j.lfs.2021.119791

Experimental method

X-RAY DIFFRACTION (2.00006351943 Å)